Three Component Syntheses of Pyrrolo Imidazole Derivatives in the Presence of N-methyl imidazole, Activated Acetylenes and Phenylsulfonylacetophenone
author
Abstract:
Because of the significant role in biological processes in living cells and the diverse types of physiological activities, heterocyclic compounds are in focus of intense investigations by academic, industry and applied-oriented chemists. Considerably, ascientific renaissance of heterocycles during the last decades is closely related to the development of multicomponent approaches to their synthesis. Multicomponent methodology is fundamentally different from two-component or sequential processestogether with other innovative synthetic methods like microwave- and ultrasonic assisted reactions offer some new possibilities in constructing heterocyclic systems with high level of molecular diversity and complexity. Among them Imidazoles are quite important reagents in modern heterocyclic chemistry, and their reactions with electrophiles are the most widespread and facile synthetic approach for obtaining diverse heterocyclic systems containing Imidazolemoiety. An interest on these heterocycles is attributed to their known biological activities: analgesics, cardiovascular vasodilators, calcium channel blocking agents, potassium channel inhibitors, apoptosis-inducers, and so on. In this research, N-methyl imidazole reacts smoothly with dialkylacetylenedicarboxylates in the presence of phenylsulfonyl acetone to produce pyrroloimidazole derivatives in good yields.
similar resources
three component syntheses of pyrrolo imidazole derivatives in the presence of n-methyl imidazole, activated acetylenes and phenylsulfonylacetophenone
full text
Application of Water for Synthesis of Cyclopentadienes via Multi-component Reactions of N-methyl imidazole
A water-accelerated multi-component synthesis of organic target molecules was used as a key method for the preparation of cyclopentadiene derivatives. The three-component condensation reactions of primary amines with alkyl propiolates in the presence of N-methylimidazole in water at room temperature were developed as efficient and clean green synthetic procedures for the high-yielding preparati...
full textOne pot three-component synthesis of imidazole derivatives using NH3/NH4Cl
Imidazole is a planar, five membered heteroaromatic molecule with pyrrole type and pyridine type annular nitrogens. Several approaches are available of imidazoles from alpha halo ketones, aminonitrile, aldehyde ect. Reactivity of imidazole and benzimidazole is referred from sets of resonance structure in which the dipolar contributors have finite importance. Imidazoles among the principal grou...
full textDesign and Synthesis of 2-Methyl and 2-Methyl-4-Nitro Imidazole Derivatives as Antifungal Agents
Two series (a and b) of N- substituted heteroaromatic compounds related to clotrimazole were synthesized. Imidazole ring of the clotrimazole was replaced by 2-methylimidazole in series a, and by 2-methyl-4-nitroimidazole in series b. O-cholortrityl moiety of clotrimazole was also replaced by trityl, mono or dimethoxy trityl. Chemical structures...
full textdetermination of olanzapine and thiourea using electrodes modified by dna and film of copper-cobalt hexacyanoferrate & investigation of electro-oxidation of some catechol derivatives in the presence of 4-phenylsemicarbazid
چکیده هدف از این کار بررسی الکترواکسیداسیون کتکول و مشتقات آن در حضور 4-فنیل سمی کاربامازید بوده است اکسیداسیون کتکولها ترکیبات نا پایدار کینونها را تولید می کنند که این ترکیبات می تواند در واکنش مایکل بعنوان پذیرنده نوکلئوفیل عمل نمایند. در ادامه اکسایش کتکولهای (a-c1) را درحضور 4-فنیل سمی کاربامازید در محلول آب/استونیتریل (90/10)بوسیله ولتامتری چرخه ای و کولن متری در پتانسیل ثابت مورد بررسی ...
15 صفحه اولMy Resources
Journal title
volume 9 issue 3
pages 27- 32
publication date 2015-07-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023